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Pharmaceutical Expert Witness

Paul Abato Consulting

Paul Abato Consulting

35 Forest Street
Providence, Rhode Island 02906

Phone(401) 379-9364

Website paulabatoconsulting.com
E-mail  Send an email

Expert WitnessSpeaker
My services have been retained by a major generic pharmaceutical drug company in a high profile case, I was deposed and participated in pretrial preparation.

Currently, I am providing expert witness consulting services in an ongoing case for a nutraceutical company where I have been deposed and am involved in pretrial preparation.

I am also presently consulting for H3 Biomedicine where I oversee radio-labled syntheses of active pharmaceutical agents for pharmacokinetic studies in rodent and higher species.

A Ph. D. Medicinal Chemist with over 20 years of experience in the discovery and development of novel human therapeutics in the areas of anti-infective, anti-inflammatory and neurodegenerative diseases.

I have been involved in all aspects of drug research and development from synthesis/purification, in-vitro, in-vivo (efficacy and pharmacokinetics) testing, dosing routs, formulation, stability testing and the management of CROs to support pre-clinical testing. I have co-authored a pre-IND proposal that had a favorable review by the FDA in January of 2013.

Services

Dr. Abato provides professional consulting and expert witness services in the area of pharmaceutical technology. His expertise includes drug research, formulation, drug development, efficacy, pharmacokinetics, dosing routs, and pre-clinical testing.

Areas of Expertise

Additional Expertise:

Medicinal Chemistry, Formulations, Drug Development, Drug Research, Nutraceutical, ANDA

More Information

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Publications

Paul Abato and Todd Bowser- 7-Disubstituted-Ph tetracycline compounds for the Treatment of SMA
From PCT Int. Appl (2013) WO2013-US43363, Patent No.WO2013181391, Priority Appl. No. US2012-61653262.

PTK-SMA2, A novel splice-correcting tetracycline derivative, increases SMN protein expression and significantly improves survival in Type I SMA mice. Paul Abato, Francine Jodelka, Paul Higgins, Jie-Zhang Hoover, Kevin Klausner, Caroline Dudley, Juan Du, Sujatha Kumar, Michelle Hastings and Todd Bowser. Poster presented at the 2012 Annual Families of Spinal Muscular Atrophy meeting in Bloomington, MN, June 21-23rd 2012.

Abato, Paul; Bowser, Todd; Higgins, Paul; Verma, Atul; Zhang-Hoover, Jie. Tetracycline Compounds for the Treatment of Rheumatoid Arthritis and Related Methods of Treatment.
From PCT Int. Appl.(2010),WO2010033939A120100325.

Hastings ML, Berniac J, Liu YH, Abato P, Jodelka FM, Barthel L, Kumar S, Dudley C, Nelson M, Larson K, Edmonds J, Bowser T, Draper M, Higgins P, Krainer AR. Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy. Sci Transl Med. (2009) Nov 4;1(5)

Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bhatia, Beena; Bowser, Todd; Grier, Mark; Honeyman, Laura; Ismail, Mohamed; Kim, Oak K.; Nelson, Mark; Pan, Jingwen; Verma, Atul. Substituted tetracycline compounds for treatment of bacterial infections and neoplasms. PCT Int. Appl.(2008),224 pp. CODEN: PIXXD2 WO2008079339A220080703 CAN 149:128685 CAPLUS

Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bowser, Todd; Chen, Jackson; Grier, Mark; Honeyman, Laura Preparation of 10-substituted tetracycline compounds as antibiotics. PCT Int. Appl.(2007),WO2007014154A220070201.

Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bhatia, Beena; Bowser, Todd; Chen, Jackson; Grier, Mark; Honeyman, Laura; Ismail, Mohamed Y.; Nelson, Mark; Kwasi, Ohemeng; Pan, Jingwen. Preparation of substituted tetracycline compounds for the treatment of bacterial infections and neoplasms. PCT Int. Appl. (2006), 126 pp. CODEN: PIXXD2 WO 2006047756 A2 20060504 CAN 144:450548 AN 2006:410014 CAPLUS

Nelson, Mark L.; Honeyman, Laura; Ismail, Mohamed; Bhatia, Beena; Verma, Atul K.; Warchol, Tadeusz; Bowser, Todd; Berniac, Joel; Mechiche, Rachid; Abato, Paul; Assefa, Haregewein. Synthesis of diverse tetracycline derivatives via Pd-catalyzed reactions: Creation of a large collection of novel 3rd generation tetracyclines. Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, United States, March 26-30, 2006 (2006), ORGN-454. CODEN: 69HYEC AN 2006:249168 CAPLUS

Nelson, Mark L.; Ohemeng, Kwasi; Amoo, Victor; Kim, Oak; Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bhatia, Beena; Bowser, Todd; Chen, Jackson; Grier, Mark; Hohos, Aaron; Honeyman, Laura; Ismail, Mohamed Y.; Mechiche, Rachid; Nihlawi, Mohammed; Sizensky, Emmanuelle. Preparation of substituted tetracycline analogs for use in antibiotic pharmaceutical compositions. PCT Int. Appl. (2005), 81 pp. CODEN: PIXXD2 WO 2005009943 A2 20050203 CAN 142:197754 AN 2005:99455 CAPLUS
Nelson, Mark L.; Ohemeng, Kwasi; Frechette, Roger; Abato, Paul; Assefa, Haregewein; Bandarage, Upul; Berniac, Joel; Bhatia, Beena; Chen, Jackson; Ismail, Mohamed Y.; Kim, Oak A.; Mathews, Jude; McIntyre, Laura; Nihlawi, Mohammed; Pearson, Andre; Reddy, Laxma; Sheahan, Paul; Sizensky, Emmanuelle; Tourigny, Justin; Verma, Atul K.; Viski, Peter; Warchol, Tadeusz. Preparation of substituted tetracycline compounds for the treatment of bacterial infections and neoplasms. PCT Int. Appl. (2003), 118 pp. CODEN: PIXXD2 WO 2003079984 A2 20031002 CAN 139:292094 AN 2003:777531 CAPLUS

Paul Abato, Courtney M. Yuen, Jeanne Y. Cubanski, and Christopher T. Seto Inhibitors of Plasmin that Extend into Both the S and S' Binding Sites: Cooperative Interactions Between S1 and S2. JOC. 2002, 67(4), 1184-1191.

Paul Abato and Christopher T. EMDee: An Enzymatic Method for Determining Enantiomeric Excess. Seto. J. Am. Chem. Soc. 2001, 123, 9206-9207.

Paul Abato, Jeffrey L. Conroy, and Christopher T. Seto. Combinatorial Library of Serine and Cysteine Protease Inhibitors that Interact with Both the S and S Binding Sites. J. Med. Chem. 1999, 42, 4001-4009.

Jeffrey L. Conroy, Paul Abato, Mousumi Ghosh, Mariana I. Austermuhle, Michel R. Kiefer, and Christopher T. Seto. Synthesis of Cyclohexanone-Based Cathepsin B Inhibitors that Interact with Both the S and S Binding Sites., Tetrahedron Lett. 1998, 39, 8253-8255.


Education

Brown University Providence RI, 6/01/96 2/12/02
Ph. D., Chemistry February 2002, Advisor: Prof. Christopher T. Seto
Thesis Title: The Development of A New Class of Protease Inhibitors and EMDee: A New High - Throughput Enzymatic Method For The Determination of Enantiomeric Excess

Rhode Island College, Providence, RI B.A, 9/01/92 - 5/01/96
Chemistry with a minor in Biology; Awarded Excellence in Organic Chemistry by the American Polymer Society.





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