Pharmaceutical Chemistry Expert Witness
Dr. Abato is a Medicinal Chemist. His expertise includes drug research, medicinal chemistry, organic chemistry, drug formulation for; IT, IV, IP, ICV, IN, IM and oral dosing routs, stability studies, extensive structure-activity relationships, efficacy, pharmacokinetics, as well as all pre-clinical testing required for IND submission to the FDA.
Dr Abato was awarded the prestigious “Heroes of Chemistry Award” by the American Chemical Society in 2019 for his contribution to NUZYRA, the latest antibiotic that works on antibacterial resistant bacteria.
Additionally, he has developed qualified clinical candidates for Spinal Muscular Atrophy (SMA) and Multiple Sclerosis. As a Medicinal Chemist, Dr Abato has also conducted research in the areas of Malaria, Tuberculosis and Cancer.
Dr Abato provides consulting services for medicinal chemistry, drug formulation, chemistry manufacturing and controls, literature search/summary and management of CROs. Presently Dr Abato is consulting for Bill and Melinda Medical Research Institute.
EXPERT WITNESS CONSULTING
Dr Abato has been involved in 6 cases, been deposed 3 times and has testified at trial in a federal court.
He has consulted for major players on the generic and branded side. Dr Abato is familiar with Hatch-Waxman / ANDA type litigation. He has also been involved with a high stakes trademark infringement case within the synthetic biology market space.
Upload Dr Abato's CV found on the link below, which includes a complete list of case numbers and Law Firms that he has represented.
Dr. Abato provides professional consulting and expert witness services in the area of pharmaceutical technology. His expertise includes drug research, drug formulation, pharmacokinetics and pre-clinical testing.
Areas of Expertise
Paul Abato Consulting in the Social NetworksLinkedIn
Paul Abato and Todd Bowser- 7-Disubstituted-Ph tetracycline compounds for the Treatment of SMA
From PCT Int. Appl (2013) WO 2013-US43363, Patent No.WO 2013181391, Priority Appl. No. US 2012-61653262.
“PTK-SMA2, A novel splice-correcting tetracycline derivative, increases SMN protein expression and significantly improves survival in Type I SMA mice.” Paul Abato, Francine Jodelka, Paul Higgins, Jie-Zhang Hoover, Kevin Klausner, Caroline Dudley, Juan Du, Sujatha Kumar, Michelle Hastings and Todd Bowser. Poster presented at the 2012 Annual Families of Spinal Muscular Atrophy meeting in Bloomington, MN, June 21-23rd 2012.
Abato, Paul; Bowser, Todd; Higgins, Paul; Verma, Atul; Zhang-Hoover, Jie. Tetracycline Compounds for the Treatment of Rheumatoid Arthritis and Related Methods of Treatment.
From PCT Int. Appl. (2010), WO 2010033939 A1 20100325.
Hastings ML, Berniac J, Liu YH, Abato P, Jodelka FM, Barthel L, Kumar S, Dudley C, Nelson M, Larson K, Edmonds J, Bowser T, Draper M, Higgins P, Krainer AR. Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy. Sci Transl Med. (2009) Nov 4;1(5)
Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bhatia, Beena; Bowser, Todd; Grier, Mark; Honeyman, Laura; Ismail, Mohamed; Kim, Oak K.; Nelson, Mark; Pan, Jingwen; Verma, Atul. Substituted tetracycline compounds for treatment of bacterial infections and neoplasms. PCT Int. Appl. (2008), 224 pp. CODEN: PIXXD2 WO 2008079339 A2 20080703 CAN 149:128685 CAPLUS
Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bowser, Todd; Chen, Jackson; Grier, Mark; Honeyman, Laura Preparation of 10-substituted tetracycline compounds as antibiotics. PCT Int. Appl. (2007), WO 2007014154 A2 20070201.
Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bhatia, Beena; Bowser, Todd; Chen, Jackson; Grier, Mark; Honeyman, Laura; Ismail, Mohamed Y.; Nelson, Mark; Kwasi, Ohemeng; Pan, Jingwen. Preparation of substituted tetracycline compounds for the treatment of bacterial infections and neoplasms. PCT Int. Appl. (2006), 126 pp. CODEN: PIXXD2 WO 2006047756 A2 20060504 CAN 144:450548 AN 2006:410014 CAPLUS
Nelson, Mark L.; Honeyman, Laura; Ismail, Mohamed; Bhatia, Beena; Verma, Atul K.; Warchol, Tadeusz; Bowser, Todd; Berniac, Joel; Mechiche, Rachid; Abato, Paul; Assefa, Haregewein. Synthesis of diverse tetracycline derivatives via Pd-catalyzed reactions: Creation of a large collection of novel 3rd generation tetracyclines. Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, United States, March 26-30, 2006 (2006), ORGN-454. CODEN: 69HYEC AN 2006:249168 CAPLUS
Nelson, Mark L.; Ohemeng, Kwasi; Amoo, Victor; Kim, Oak; Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bhatia, Beena; Bowser, Todd; Chen, Jackson; Grier, Mark; Hohos, Aaron; Honeyman, Laura; Ismail, Mohamed Y.; Mechiche, Rachid; Nihlawi, Mohammed; Sizensky, Emmanuelle. Preparation of substituted tetracycline analogs for use in antibiotic pharmaceutical compositions. PCT Int. Appl. (2005), 81 pp. CODEN: PIXXD2 WO 2005009943 A2 20050203 CAN 142:197754 AN 2005:99455 CAPLUS
Nelson, Mark L.; Ohemeng, Kwasi; Frechette, Roger; Abato, Paul; Assefa, Haregewein; Bandarage, Upul; Berniac, Joel; Bhatia, Beena; Chen, Jackson; Ismail, Mohamed Y.; Kim, Oak A.; Mathews, Jude; McIntyre, Laura; Nihlawi, Mohammed; Pearson, Andre; Reddy, Laxma; Sheahan, Paul; Sizensky, Emmanuelle; Tourigny, Justin; Verma, Atul K.; Viski, Peter; Warchol, Tadeusz. Preparation of substituted tetracycline compounds for the treatment of bacterial infections and neoplasms. PCT Int. Appl. (2003), 118 pp. CODEN: PIXXD2 WO 2003079984 A2 20031002 CAN 139:292094 AN 2003:777531 CAPLUS
Paul Abato, Courtney M. Yuen, Jeanne Y. Cubanski, and Christopher T. Seto Inhibitors of Plasmin that Extend into Both the S and S' Binding Sites: Cooperative Interactions Between S1 and S2. JOC. 2002, 67(4), 1184-1191.
Paul Abato and Christopher T. EMDee: An Enzymatic Method for Determining Enantiomeric Excess. Seto. J. Am. Chem. Soc. 2001, 123, 9206-9207.
Paul Abato, Jeffrey L. Conroy, and Christopher T. Seto. Combinatorial Library of Serine and Cysteine Protease Inhibitors that Interact with Both the S and S' Binding Sites. J. Med. Chem. 1999, 42, 4001-4009.
Jeffrey L. Conroy, Paul Abato, Mousumi Ghosh, Mariana I. Austermuhle, Michel R. Kiefer, and Christopher T. Seto. Synthesis of Cyclohexanone-Based Cathepsin B Inhibitors that Interact with Both the S and S' Binding Sites., Tetrahedron Lett. 1998, 39, 8253-8255.
Brown University Providence RI, 6/01/96 – 2/12/02
Ph. D., Chemistry February 2002, Advisor: Prof. Christopher T. Seto
Thesis Title: The Development of A New Class of Protease Inhibitors and EMDee: A New High - Throughput Enzymatic Method For The Determination of Enantiomeric Excess
Rhode Island College, Providence, RI B.A, 9/01/92 - 5/01/96
Chemistry with a minor in Biology; Awarded Excellence in Organic Chemistry by the American Polymer Society.