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Tobias A. Mattei, MD - Assistant Professor of Neurosurgery - Saint Louis University

Tobias A. Mattei, MD - Assistant Professor of Neurosurgery - Saint Louis University

63 S Woods Mill Rd
Chesterfield, Missouri 63017

Phone(614) 403-2731


► Contact Tobias A. Mattei, MD - Assistant Professor of Neurosurgery - Saint Louis University

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I am a fellowship-trained academic neurosurgeon specialized in complex spine/deformity surgery, currently practicing as Assistant Professor of the Division of Neurosurgery of St. Louis University. I have been an active member of the North American Spine Society, American Association of Neurological Surgeons, Congress of Neurological Surgeons as well as many other international societies.

I am member of the editorial board of The Spine Journal and Deputy Editor of the North American Spine Society Journal, the new open access initiative of the North American Spine Society. I am an active reviewer of several other neurosurgical journals including World Neurosurgery, Clinical Neurology & Neurosurgery, Journal of Clinical Neuroscience, Osteoarthritis & Cartilage, Journal of Engineering in Medicine: Part H, British Journal of Neurosurgery and Neurological Sciences.

I have already provided expert review services for several scientific funding agencies in the U.S. (including the NIH Panel for Clinical Neurophysiology, Devices, Neuroprosthetics and Biosensors) as well as abroad (including the Innovation and Technology Commission/ Hong Kong SAR Government and The Brain Tumor Charity - New Ideas Award/UK). As medical expert witness I provide services in the field of spine surgery and neurosurgery.

As a researcher, I have published more than 130 original research articles, having been cited more than 1400 times. I am board certified by the American Board of Clinical Neurological Surgery and the World Federation of Neurosurgical Societies. I hold an unrestricted medical license in the state of Ohio, Missouri, New York and Maine, having never been submitted to any sanction or disciplinary action by the respective medical boards.


Mr. Mattei offers the following services: Medical Expert Witness; Medical Records Review; Expert opinion on Medical Malpractice cases.

Areas of Expertise

Additional Expertise:

Lumbar Disc Herniation, Cervical Disc Herniation, Failed Back Syndrome, Artificial Disc Replacement, Spinal Cord Stimulation, Kyphoplasty, Spinal Stenosis; Lumbar Fusion; Cervical Fusion; Anterior Cervical Discectomy and Fusion; Cervical Arthroplasty; Vertebroplasty; Failed Back Syndrome; Peripheral Nerve Surgery; Spinal Tumors; Spinal Fractures; Carpal Tunnel Surgery; Ulnar Nerve Release.

Areas Served

All States

Tobias A. Mattei, MD - Assistant Professor of Neurosurgery - Saint Louis University in the Social Networks

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Professional Experience

I have been an active neurosurgeon/spine surgeon for the past 5 years, currently focused on complex spine surgery and scoliosis.


Active unrestricted physician licenses at the states of New York, Missouri, Ohio and Maine.


Saint Louis University - Division of Neurosurgery


Board-certification in neurosurgery:
World Federation of Neurosurgical Societies; American Board of Clinical Neurological Surgery;
Brazilian Society of Neurosurgery

Awards & Honors

North American Spine Society/Spine Line. 20 under 40's. Best Spine Surgeons.


Peer Reviewed Publications:
- Mattei TA.S3 Sacral-Alar Iliac Screw: A Salvage Technique for Pelvic Fixation in Complex Deformity Surgery. World Neurosurg. 2020 Mar 16;139:23-30. doi: 10.1016/j.wneu.2020.03.025. [Epub ahead of print]
- Mattei TA, Perret CM. Should kyphoplasty curettes be used in nonosteoporotic patients? A cautionary tale. Clin Case Rep. 2020 Jan 30;8(3):453-460. doi: 10.1002/ccr3.2670. eCollection 2020 Mar.
- Mattei TA, Teasdale GM. The Story of the Development and Adoption of the Glasgow Coma Scale: Part I, The Early years. World Neurosurg. 2019 Nov 8. pii: S1878-8750(19)32831-1. doi: 10.1016/j.wneu.2019.10.193. [Epub ahead of print]
- Mattei TA. Nonstatistically Significant but Still Different? Perils of Affirming the Alternative (H1) Hypothesis in the Absence of Statistical Significance. World Neurosurg. 2019 Nov;131:288. doi: 10.1016/j.wneu.2019.06.061.
- Lyons FG, Mattei TA. Sources, Identification, and Clinical Implications of Heterogeneity in Human Umbilical Cord Stem Cells. Adv Exp Med Biol. 2019;1169:243-256. doi: 10.1007/978-3-030-24108-7_13.
- Kluzek S, Mattei TA. Osteoarthritis Cartilage. 2019 Jul;27(7):977-978. doi: 10.1016/j.joca.2019.04.005. Epub 2019 Apr 17.
- Mattei TA, Perret CM, Nunes JC. Development of a New Coupled Cobb-Suction Instrument for Posterior Spinal Approaches: Technical Note. World Neurosurg. 2019 Feb 15. pii: S1878-8750(19)30353-5. doi: 10.1016/j.wneu.2019.01.240. [Epub ahead of print]
- Mattei TA, Goulart CR, Rai SS, Rehman AA, Williams M, Mendel E. Rapid Development of Spinal Epidural Lipomatosis after Treatment of Metastatic Castration-resistant Prostate Cancer with Second-Generation Androgen Receptor Antagonists. World Neurosurg. 2019 Feb 11. pii: S1878-8750(19)30334-1. doi: 10.1016/j.wneu.2019.01.222. [Epub ahead of print]
-Nunes JC, Perret C, Ordookhanian C, Kaloostian PE, Abdulrauf SI, Mattei TA.“Crimes against the Nervous System”: Neurological References During the Nuremberg Doctors' Trials. World Neurosurg. 2018 Oct 24. pii: S1878-8750(18)32390-8. doi: 10.1016/j.wneu.2018.10.092. [Epub ahead of print]
-Ordookhanian C, Kaloostian PE, Mattei TA. Taming the Opioid Epidemic: The NIH HEAL Initiative. World Neurosurg. 2018 Oct 3. pii: S1878-8750(18)32260-5. doi: 10.1016/j.wneu.2018.09.205. [Epub ahead of print]
- Mattei TA. "Reinventing the wheel": reflections on a recurrent phenomenon in the history of neurosurgery. J Neurosurg. 2018 Sep 14:1-8. doi: 10.3171/2018.4.JNS18652. [Epub ahead of print]
- Mattei TA.The CRISPR-Cas9 Genome Editing System: Not as Precise as Previously Believed. World Neurosurg. 2018 Aug 14. pii: S1878-8750(18)31825-4. doi: 10.1016/j.wneu.2018.08.042. [Epub ahead of print]
- Mattei TA. Practical Effects of Lowering the P Value in Neurosurgery: Restricting Evidence-Based Medicine to Big Business. World Neurosurg. 2018 Sep;117:460-462. doi: 10.1016/j.wneu.2018.07.112. Epub 2018 Jul 18.
- Mattei TA. Memory Transplantation and Learning by Proxy? A Sober Assessment of the Popularly Acclaimed "Snails Experiment". World Neurosurg. 2018 Aug;116:387-389. doi: 10.1016/j.wneu.2018.06.129. Epub 2018 Jun 21.
- Mattei TA. Letter to the Editor. S-1 alar-iliac screw technique: nothing new under the sun. J Neurosurg Spine. 2018 Sep;29(3):346-347. doi: 10.3171/2018.2.SPINE18173. Epub 2018
- Mattei TA, Ordookhanian C, Kaloostian PE.. "Dear Anesthesiologist, Please Don't Abandon Us": Excessive Anesthesia Handovers and Adverse Perioperative Outcomes in Neurosurgery. World Neurosurg. 2018 Jul;115:254-256. doi: 10.1016/j.wneu.2018.05.029. Epub 2018 May 19.
- Mattei TA. Rope Jumping-Induced Traumatic Compression Fractures: the Underestimated Danger of Repetitive Axial Load Forces. World Neurosurg. 2018 May;113:96-97. doi: 10.1016/j.wneu.2018.02.037. Epub 2018 Feb 14.
- Mattei TA. A game theory appraisal of the insurance hypothesis: Specific polymorphisms in the energy homeostasis network as imprints of a successful minimax strategy. Behav Brain Sci. 2017 Jan;40:e123. doi: 10.1017/S0140525X16001485.
- Mattei TA. Privacy, Confidentiality, and Security of Health Care Information: Lessons from the Recent WannaCry Cyberattack. World Neurosurg. 2017 Aug;104:972-974. doi: 10.1016/j.wneu.2017.06.104. Epub 2017 Jun 21.
- Mattei TA. The specificity of SPECT-CT for the diagnosis of discogenic pain: implications for the future of the lumbar fusion outcome score (LUFOS). Spine J. 2018 Sep;18(9):1722-1724. doi: 10.1016/j.spinee.2018.04.020. No abstract available.
- Mattei TA Academia's Reproach of Trump's Travel Ban: The Magnitude of the Response. World Neurosurg. 2017 Jul;103:896-898. doi: 10.1016/j.wneu.2017.04.168. Epub 2017 May 3.
- Mattei TA, Beer J, Teles AR, Rehman AA, Aldag J, Dinh D.Clinical Outcomes of Total Disc Replacement Versus Anterior Lumbar Interbody Fusion for Surgical Treatment of Lumbar Degenerative Disc Disease. Global Spine J. 2017 Aug;7(5):452-459. doi: 10.1177/2192568217712714. Epub 2017 Jul 7.
- Mattei TA. Privacy, Confidentiality, and Security of Health Care Information: Lessons from the Recent WannaCry Cyberattack. World Neurosurg. 2017 Aug;104:972-974. doi: 10.1016/j.wneu.2017.06.104. Epub 2017 Jun 21.
- Mattei TA. Cavitational kyphoplasty: a new technique for reducing the rates of cement extravasation through targeted low-pressure cement injection. Acta Neurochir (Wien). 2017 Jun;159(6):1153-1157. doi: 10.1007/s00701-017-3167-3. Epub 2017 Apr 5.
- Mattei TA. Teles AR. Letter to the Editor: The ancient "apples and oranges" conundrum: a call for methodological precision. J Neurosurg Spine. 2017 Mar 24:1-3. doi: 10.3171/2016.10.SPINE161185. [Epub ahead of print]
- Mattei TA. The Fractal Geometry of the Brain: Book Review. World Neurosurgery 100:271-272 · April 2017 DOI: 10.1016/j.wneu.2017.01.018
- Mattei TA. A game theory appraisal of the insurance hypothesis: Specific polymorphisms in the energy homeostasis network as imprints of a successful minimax strategy. Behavioral and Brain Sciences 40 · January 2017. DOI: 10.1017/S0140525X16001485
- Teles AR, Mattei TA, Righesso O, Falavigna A. Effectiveness of Operative and Nonoperative Care for Adult Spinal Deformity: Systematic Review of the Literature. Global Spine J. 2017 Apr;7(2):170-178. doi: 10.1177/2192568217699182. Epub 2017 May 1.
- Mattei TA. Proposition 64, Cannabis Legalization, and the California Secession Movement: Why Should Neurosurgeons Care?
World Neurosurg. 2017 Mar;99:770-772. doi: 10.1016/j.wneu.2017.01.066.
- Mattei TA. Talking to Others' Selves: Why a valuationial paradigm of agency fails to provide an adequate theoretical framework for moral Responsibility, social accountability and legal liability. Behav Brain Sci. BBS-D-17-00130_ Doris_ Mattei. (Jan 2017 - in press)
- Mattei TA. Trump, Obamacare and the Market for ‘Lemons' Paradigm: Current Perspectives on the Future of U.S. Health Care. World Neurosurg. 2017 Feb;98:829-832. doi: 10.1016/j.wneu.2016.12.082.
- Mattei TA, Rehman AA, Goulart CR, Sória MG, Rizelio V, Meneses MS. Successful outcome after endovascular thrombolysis for acute ischemic stroke with basis on perfusion-diffusion mismatch after 24 h of symptoms onset. Surg Neurol Int. 2016 Jun 3;7(Suppl 14):S421-6. doi: 10.4103/2152-7806.183522.
- Mattei TA, Rehman AA, Teles AR, Aldag JC, Dinh DH, McCall TD. The 'Lumbar Fusion Outcome Score' (LUFOS): a new practical and surgically oriented grading system for preoperative prediction of surgical outcomes after lumbar spinal fusion in patients with degenerative disc disease and refractory chronic axial low back pain. Neurosurg Rev. 2016 Jun 11. [Epub ahead of print]
- Mattei TA, Teles AR, Dinh DH. Vertebral body fracture after anterior cervical discectomy and fusion with zero-profile anchored cages in adjacent levels: a cautionary tale. Eur Spine J. 2016 Jan 5. [Epub ahead of print]
- Mattei TA. Right L4/L5 Extreme-Lateral Interbody Fusion (XLIF) for Adult Degenerative Scoliosis: When the Black Swan is too real…. World Neurosurg. 2015 Oct 16. pii: S1878-8750(15)01372-8. doi: 10.1016/j.wneu.2015.10.029. [Epub ahead of print]
- Mattei TA, Rehman AA, Dinh DH. Acute Spinal Subdural Hematoma after Vertebroplasty: A Case Report Emphasizing the Possible Etiologic Role of Venous Congestion. Global Spine J. 2015 Oct;5(5):e52-8. doi: 10.1055/s-0035-1544155. Epub 2015 Feb 2.
- Goulart CR, Mattei TA, Fiore ME, Thoman WJ, Mendel E. Retropharyngeal abscess with secondary osteomyelitis and epidural abscess: proposed pathophysiological mechanism of an underrecognized complication of unstable craniocervical injuries: case report. J Neurosurg Spine. 2015 Sep 25:1-9. [Epub ahead of print]
- Mattei TA, Rehman AA, Issawi A, Fassett DR. Surgical challenges in the management of cervical kyphotic deformity in patients with severe osteoporosis: an illustrative case of a patient with Hajdu-Cheney syndrome. Eur Spine J. 2015 Jul 22. [Epub ahead of print]
- Mattei TA. Alternating Electric Fields and Carcinogenesis: A New Paradigm to Avoid Missing the Elephant in the Room. World Neurosurg. 2015 Mar 10. pii: S1878-8750(15)00197-7. doi: 10.1016/j.wneu.2015.03.003. [Epub ahead of print]
- Rehman AA, Elmore KB, Mattei TA. The effects of alternating electric fields in glioblastoma: current evidence on therapeutic mechanisms and clinical outcomes. Neurosurg Focus. 2015 Mar;38(3):E14. doi: 10.3171/2015.1.FOCUS14742.
- Mattei TA. Author's reply to "how to use the load-sharing classification of spine fractures?" Avoiding misleading randomization of apples, oranges and other citruses: the necessity of proper evaluation of comminution in classification systems of thoracolumbar fractures. Eur Spine J. 2015 Feb;24(2):408-11. doi: 10.1007/s00586-014-3714-z. Epub 2014 Dec 17.
- Mattei TA. Speech as a breakthrough signaling resource in the cognitive evolution of biological complex adaptive systems. Behav Brain Sci. 2014 Dec;37(6):563-4; discussion 577-604. doi: 10.1017/S0140525X13004111.


Residency in Neurosurgery - Institute of Neurology of Curitiba - 2006-2011
Fellowship in Spine Surgery - The University of Illinois at Peoria - 2011-2013
Fellowship in Complex Oncological Spine Surgery and Reconstruction - 2013-2014

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